The relationship of clinicopathology and immunophenoty pes in non-Hodgkin's lymphomas of the spleen
10.3760/j.issn:0529-5807.2001.02.003
- VernacularTitle:脾脏非霍奇金淋巴瘤的临床病理特征及其与免疫表型的关系
- Author:
Weiping LIU
1
;
Zirong YANG
;
Linhua ZENG
;
Gandi LI
;
Wenyan ZHANG
;
Fengyuan LI
Author Information
1. West-China University of Medical Sciences
- From:
Chinese Journal of Pathology
2001;30(2):93-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between clinicopathologic features and immunophenotypes in non-Hodgkin's lymphoma (NHL) of the spleen. Methods Clinicopathologic analysis and follow up; immunohistologic staining by SP method and EBER in situ hybridization. Results (1) Splenomegaly was found in al l 19 cases of spleen NHL, 10 of the 19 (52.6%) cases had masses or a mass in the ir enlarged spleen; (2) 14 of the 19 (73.7%) cases were of B-cell type (includi n g 5 cases of follicular type and 9 cases of diffuse type) ,in which 8 cases were centroblastic, 3 of centroblast/centrocyte and 4 cases of s mall lymphocyte types; all 10 cases of primary splenic lymphomas (PSL) were B-c ell type ; (3) 5 of the 19 cases (26.3%) had peripheral T-cell origin, including 4 cases of large cell type and 1 case of small cell type; of the 3 TIA-1 positive cases , 2 we re also positive for EBER 1/2 (one CD 8+ and another CD56+), the remaining case was CD8-, CD56-, EBER1/2-; all 5 cases were secondary NHL of the spleen; (4) Fol lo w up data were obtained for 14/19 cases (73.7%). 8 of 9 surviving cases were pri m ary NHL. The range of survival period varied from 8 to 10 years. All 5 deceased cases had secondary NHL and their survival period was 2 to 6 months. Conclusions Some relationship exists between the clinicopathology and origin of the tumor c ells in splenic NHL, the prognosis of primary NHL is better than that of the sec ondary NHL and the diagnosis of primary NHL should be made with discretion.
