Research progress on the possible mechanism of dexmedetomidine in preventing contrast-induced acute kidney injury
- VernacularTitle:右美托咪定预防造影剂诱导急性肾损伤机制的研究进展
- Author:
Jinze LI
1
;
Kai LI
;
Guoqing ZHAO
Author Information
- Keywords: Dexmedetomidine; Contrast medium; Acute kidney injury
- From: The Journal of Clinical Anesthesiology 2024;40(5):541-544
- CountryChina
- Language:Chinese
- Abstract: Contrast-induced acute kidney injury(CI-AKI)is an iatrogenic acute kidney injury(AKI)observed after diagnostic or therapeutic angiographic interventions with the intravascular application of contrast media(CM).CM leads to impaired renal function through tubular toxicity,intrarenal vasocon-striction,and excessive reactive oxygen species(ROS)production.Dexmedetomidine(DEX)is a selective α2 adrenergic receptor agonist that has been shown to have good antioxidant and anti-inflammatory effects,and its organ protective effect in the perioperative period is increasingly prominent.Several studies have found that DEX has an excellent protective effect on postoperative renal function.This article aims to explore the protective effect,possible mechanism,and clinical application of DEX in CI-AKI.
