DNA ploidy analysis and Ki-67 examination on renal neoplasms：investigation of degree of malignancy and biological behavior of small renal tumors

VernacularTitle:DNA倍体分析及Ki-67检测对肾实质小肿瘤性质和意义的探讨
Author: Lina LIU ¹ ; Changhuai ZHANG
Author Information

1. Beijing Friendship Hospital
From: Chinese Journal of Pathology 2001;30(1):39-42
CountryChina
Language:Chinese
Abstract: Objective　To investigate the degree of malignancy and the biological behavior of small renal tumors and provide a pathological basis for clinicians in determination of further treatment and prognosis. Methods　Flow cytometry and immunohistochemical studies were performed on 48 small tumors with diameters less than 3 cm. and 39 renal cell carcinomas with diameters larger than 3 cm in comparison to assess their DNA ploidy status and Ki-67 PR (proliferation rate). Results　Of the 48 small renal tumors, 6 adenoma were all diploid with low PR (<1%). Aneuploid rate of 42 small renal tumors with clear and granular cell type was 16.7%, showing no statistical difference with the 33.3% aneuploid rate of 39 large renal cell carcinomas. 42 small renal tumors had a lower mean PR than large renal cell carcinoma. DNA ploidy correlated closely with nuclear grade, stage and histological type. There existed a close relation between PR and grade. Conclusion　Small renal tumors consist of both adenoma and carcinoma, therefore tumor size can not be used as a criterion in their differential diagnosis. DNA ploidy and Ki-67 PR are important indicators for predicting the biological behavior and prognosis of renal parenchymal tumors.