E-cadherin associated protein expression and its significance in invasive lobular carcinoma and invasive ductal carcinoma of breast
10.3760/j.issn:0529-5807.2001.01.008
- VernacularTitle:上皮钙依赖粘附素相关分子在乳腺浸润性小叶癌和导管癌中的表达及意义
- Author:
Anjia HAN
1
;
Min XIONG
;
Zhi LI
;
Yingjie LIANG
Author Information
1. Sun Yat-sen University of Medical Sciences
- From:
Chinese Journal of Pathology
2001;30(1):27-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study E-cadherin associated proteins α-、β-、γ-catenin expression and their significance in invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) of breast. Methods Immunohistochemistry staining (labeled streptavidin-biotin method) was used to detect α-、β-、γ-catenin expression in invasive breast carcinoma (19 cases of ILC and 32 cases of IDC ). Results The loss and reduction rate of α-、β-、γ-catenin expression in ILC was 78.9% (15 cases)，52.6%(10 cases) and 84.2%(16 cases), respectively. The rate of α-、β-、γ-catenin expression showing loss and reduction in IDC was 75.0%(24 cases)，43.8%(14 cases) and 81.3%(26 cases), respectively. The staining intensity of α-、β-、γ-catenin expression in invasive carcinoma of breast was weaker than that in foci of carcinoma in situ (semiquantitative grading). There was a positive relationship between the expression of α-catenin and β-catenin in invasive breast carcinoma. No significant association was seen between reduced protein expression of α-、β-、γ-catenin and the development of lymph node metastasis. Conclusion α-、β-、γ-catenin expression was almost identical in ILC and IDC of breast, showing significant loss and reduction of protein expression in the carcinoma cells of invasive breast carcinoma, suggesting that α-、β-、γ-catenin may lose their normal adherent ability in the pathogenesis of invasive breast carcinoma.
