The Influence of Finasteride on Incidence and Pathology Grading of Prostate Cancer

VernacularTitle:非那雄胺对前列腺癌发生率及病理分级的影响
Author: ZHU JIE ¹ ; GAO JIANGPING ; HONG BAOFA ; SHI HUAIYIN ; CUI LIANG ; DU QINGSHAN ; ZHANG XUN
Author Information

1. 解放军总医院
Keywords: prostate cancer; finasteride; incidence; pathology grading
From: Journal of Clinical Urology 2009;24(7):515-519
CountryChina
Language:Chinese
Abstract: Objective:To evaluate the influence of finasteride on incidence and pathology grading of prostate ca-ner in China. Methods:Depend on the medication, 1029 patients with benign prostatic hyperplasia (BPH) were di-vided into 4 groups: finasteride group,α-receptor inhibitor group, eombination group and control group (non-treatment group). We gathered pathology sections of all patients, and gave Gleason Score to each. The difference the population was 13.51%. Compare with non-using of finasteride, using of it could reduee the incidence of pros-tate cancer 40.63% than non-using group's (RR = 0.59,95% CI: 0.43-0.82). There was a significant difference cancer patients was 58.27%, The ratio was quite different using finasteride and patients not (P<0.05), and it in-creased 33.96% in finasteride groups compare to not using groups(RR= 1.34,95%CI: 1.01-1.76). Conclusions: The risk of prostate eaneer in BPH patients could be decreased by finasteride treatment. But the malignant degree of prostate caner could be increased in BPH patients using finaseride.