Expression and interaciton of P21WAF1/CIP1 and P53 genes in human bladder carcinoma and the clinical significance
10.3969/j.issn.1001-1420.2001.06.012
- VernacularTitle:P21WAF1/CIP1和P53基因表达与膀胱癌生物学行为的关系
- Author:
Xing ZHOU
1
;
Hua MEI
;
Chunxiao LIU
Author Information
1. Pearl River Hospital of the First Military Medical University
- From:
Journal of Clinical Urology
2001;16(6):267-269
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the correlation between the expression and interaction of P21WAF1/CIP1 and P53 genes in bladder carcinoma and clinical prognosis.Methods:In 122 cases of bladder cancer,the expression of P21WAF1/CIP1 and P53 were assessed by immunohistochemical techniques. The results were analyzed using the double variable quantity, Logistic return and Kaplan-Meier methods.Results:Among the P53 wild-type tumors,78% were P21WAF1/CIP1 positive compared with 41% of the P53-altered tumors (P＜0.01＝;Patients with P53-altered tumors that maintained P21WAF1/CIP1 expression showed the similar rates of recurrence and overall survival compared with patients with P53 wild-type tmors.Conclusions:Maintenance of P21WAF1/CIP1 expression appears to abrogate the deleterious effects of P53 alteration on bladder cancer progression; the status of P21WAF1/CIP1 expression considering together clinical stage can more accurately judge the malignance and prognosis for bladder cancer. Then the result has a significant indicator for working out therapy scheme.
