Renal cell cancer in horseshoe kidney and the relationship between the abnormal renal development and tumorigenesis
10.3969/j.issn.1001-1420.2001.06.004
- VernacularTitle:马蹄形肾并发肾细胞癌的胚胎发生学及诊治(附3例报告)
- Author:
Tao LIN
1
;
Qiang WEI
;
Yuru YANG
;
Hong LI
;
Ming SHI
Author Information
1. the First Affiliated Hospital of Huaxi Medical University
- From:
Journal of Clinical Urology
2001;16(6):250-251
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the diagnosis and the treatment of renal cell carcinoma(RCC) in horseshoe kidney and evaluate the relationship between the embryology of the horseshoe kidney and tumorogenesis.Methods:Three cases of RCC in horseshoe kidney were presented with review of the literature of the embryology of the horseshoe kidney.Results:Radical nephrectomy was performed for all the 3 cases. 1 patient died of metastasis 3 months after surgery; the other 2 were free of tumor 1 year and 3 years postoperatively.Conclusions:RCC in horseshoe kidney is rare. The imaging techniques are essential to the diagnosis. Radical nephrectomy with resection of the isthmus is the main treatment method. Recently reported data suggest that the theory of a mechanical fusion is valid only for horseshoe kidneys with a fibrous isthmus. For the majority of horseshoe kidney with a parenchymatous isthmus,the embryological pathogenesis is considered as an abnormal migration of cells of the posterior nephrogenic area.This migration may be predisposed to the development of RCC.
