The expressions of TGFβ1 and PCNA in human renal cell carcinoma and their significance
10.3969/j.issn.1001-1420.2001.02.009
- VernacularTitle:TGFβ1及PCNA在肾细胞癌中的表达及其临床意义
- Author:
Tianxin LIN
1
;
Jian HUANG
;
Zhenghui GUO
;
Qingqing CAI
Author Information
1. Sun Yat-Sen Memorial Hospital
- From:
Journal of Clinical Urology
2001;16(2):72-74
- CountryChina
- Language:Chinese
-
Abstract:
Purpose：To study the expressions of transforming growth factor beta 1(TGFβ1) and proliferating cell nuclear antigen(PCNA) and their effects on the growth of human renal cell carcinoma.Methods:46 specimens of human renal cell carcinoma (RCC) and 11 normal kidneys as control were assessed by immunohistochemical method (SP method).Results:TGFβ1 content in RCCs was more than that in normal kidneys (P<0.05). The PCNA index in RCCs was higher than that in normal kidneys (P<0.01). The PCNA index was significantly higher in poor differentiated and invasive RCCs (P<0.05). There was a negative relationship between the content of TGFβ1 and PCNA（P<0.01）.The expected life was shorter in RCC cases with low level TGFβ1 or high level PCNA(P<0.05).Conclusions:TGFβ1 can act as a negative regulating factor and inhibit the growth of RCC, especially inhibit the proliferation of RCCs. TGFβ1 and PCNA can act as the predict factors of the progression of RCCs.
