Significance of overexpression of P-glycoprotein, mutant P53 protein and epidermal growth factor receptor in primary superficial transitional cell carcinoma of bladder
10.3969/j.issn.1001-1420.2001.02.006
- VernacularTitle:Pgp、mP53和EGFR表达预测表浅性膀胱癌复发的价值
- Author:
Huiliang ZHOU
1
;
Yiqi LUO
;
Linsheng CAO
;
Chenjie LIN
;
Weimin YE
Author Information
1. 1st Affiliated Hospital of Fujian Medical University
- From:
Journal of Clinical Urology
2001;16(2):65-67
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the prognostic value of P-glycoprotein(Pgp), mutant P53 protein and epidermal growth factor receptor (EGFR) expression in primary superficial transitional cell carcinomas(TCCs) of bladder.Methods:Specimens from 46 patients with untreated superficial bladder TCCs were analyzed for the expression of Pgp,mutant P53 and EGFR respectively and their clinical data were obtained by follow-up for over 3 years.Results:Pgp, mutant P53 protein and EGFR were positive in 45.7%,58.7% and 52.2% respectively. A strongly inverse relationship between the expression of Pgp, mutant P53 and EGFR and disease free survival (DFS)could be demonstrated by Kaplan Meier survival analysis. Multivariate analysis(Cox regression)indicated that DFS or recurrence was associated with overexpression of Pgp and mutant P53 protein, no significant correlation between EGFR overexpression and recurrence was found.Conclusions:Overexpression of Pgp, mutant P53 can be used as the important prognostic factor of recurrence of superficial TCCs.
