Intratumor mirovessel density and recurrence of transitional cell carcinoma of the bladder
10.3969/j.issn.1001-1420.2001.02.005
- VernacularTitle:膀胱移行细胞癌微血管密度与肿瘤复发的关系
- Author:
Yunbo MA
1
;
Qingzheng MA
Author Information
1. 山东省聊城市人民医院
- From:
Journal of Clinical Urology
2001;16(2):63-64
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To evaluate angiogenesis and its correlation to recurrence of transitional cell carcinoma of the bladder.Methods:Specimens from 25 patients with transitional cell carcinoma of the bladder were assayed using immunohistochemical technique to examine the expression of factor Ⅷ related antigen, basic fibroblast growth factor(bFGF) and vessel endothelial growth factor(VEGF), as well as the microvessel density.Results:The positive rate of VEGF and bFGF was 48% and 28%. The intratumor microvessel density(iMV) of tissues with positive staining was significantly higher than those with negative staining(P＜0.05),and the iMV of patients with recurrence was significantly higher than those without recurrence(P＜0.05).Conclusions:iMV correlated positively with recurrence and the expression of VEGF and bFGF was related to the function of angiogenesis in transitional cell carcinoma of the bladder.
