T-lymphocyte subsets monitoring in kidney transplant recipients undergoing severe cytomegalovirus infection or acute rejection episodes

VernacularTitle:重症巨细胞病毒感染和急性排斥肾移植受者T淋巴细胞亚群的动态变化
Author: Guang-Fu DONG ¹ ; Ren-Gao YE ; Shi-Guang ZHANG ; Hua MEI ; Qing-Yu KONG ; Pei-Geng WU
Author Information

1. the First Affilated Hospital Sun Yat-Sen Medical University
Keywords: Renal transplantation Cytomegalovirus infection Graft rejection T-lymphocytes
From: Journal of Clinical Urology 2000;15(10):466-468
CountryChina
Language:Chinese
Abstract: Purpose :To investigate the relationship of peripheral blood T-lymphocyte subsets with the acuterejection or severe CMV infection in transplanted patients. Methods :T-lymphocytes subsets of peripheral bloodwere consecutively detected by using mice-verse-human T-lymphocytes subsets monoclonal antibody-OKT serialsand flow cytometer. Results:The difference of CD4/CD8 ratios between the no acute rejection group and the acuterejection group, or between the acute rejection remission group and the resistant acute rejection group was signif-icant ( P ＜0.05); In patients with intensive CMV infection, the CD4/CD8 ratios were converse to the acute re-jection group. Conclusions:These results indicated that monitoring of peripheral blood T-lymphocyte subsets wasof much benefit to early diagnosis and differential diagnosis of acute rejection of intensive CMV infection and rea-sonable treatment.