The effect of MMF on the post-operative infections after renal transplantation

VernacularTitle:骁悉对肾移植术后感染的影响
Author: Li-Gong TANG ¹ ; Tie-Jun PAN ; Sen XIE ; Guo-Qin SHEN ; Hen-Dong WEN ; Jie-Rong YANG
Author Information

1. Wuhan General Hospital Guangzhou Military Area
Keywords: Renal transplantation MMF Immunosuppressive agents Infection
From: Journal of Clinical Urology 2000;15(10):447-448
CountryChina
Language:Chinese
Abstract: Purpose:To investigate the effect of MMF on the postoperative infection after renal transplanta-tion. Methods: Before 1997, the CsA + Aza + prednisone were used as immunosuppresive agents postoperativelyfor 56 cases; Since 1998, drugs used for 34 cases were changed into MMF and CsA+MMF+prednisone respec-tively. The dose initially used for CsA was 65 mg/kg · d 1 in the patients of Aza group and 5 mg/kg · d 1 for theMMF group and then this dosage was regulated according to the determination of plasma level of the drug. Re-sults:The total infection rate of these 90 patients was 17.8%, 12 cases were infected in the Aza group (21.4%)and 11.8% (4 cases) in the MMF group. There were 2 patients died in the Aza group. Conclusions:The postop-erative infection rate of the patients underwent kidney transplantation might be reduced when MMF was used tosubstitute Aza during the period of postoperative management.