Research on diagnostic value of thrombin-antithrombin complex,thrombomodulin and tissue plasminogen activator-inhibitor complex for COVID-19
10.13602/j.cnki.jcls.2024.10.06
- VernacularTitle:凝血酶-抗凝血酶复合物、血栓调节蛋白和组织型纤溶酶原激活物抑制物复合物对危重型新型冠状病毒感染的诊断价值
- Author:
Fengwei GAO
1
;
Lin ZHOU
;
Xiaobao SHAO
;
Hua WANG
;
Yuan YANG
;
Xin CHEN
;
Yi LIU
;
Peiyuan ZHU
Author Information
1. 南京中医药大学附属南京市中医院输血科,南京 210022
- Keywords:
Corona virus disease 2019;
critical type;
thrombin-antithrombin complex;
thrombomodulin;
tissue plasminogen activator-inhibitor complex
- From:
Chinese Journal of Clinical Laboratory Science
2024;42(10):748-753
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively analyze the diagnostic value of thrombin-antithrombin complex(TAT),thrombomodulin(TM),and tissue plasminogen activator-inhibitor complex(t-PAIC)in severe cases of corona virus disease 2019(COVID-19).Methods A cohort of 79 patients clinically diagnosed with COVID-19 was retrospectively assembled and categorized into two groups based on disease severity:non-severe(n=51)and severe(n=28).In this study the differences of coagulation function and inflamma-tory marker levels between the two groups were compared.The correlations of TAT,TM and t-PAIC with other biomarkers were investi-gated.The diagnostic values of all the markers for severe COVID-19 were assessed.Results The patients of severe COVID-19 exhibi-ted significantly higher levels of TAT,TM,and t-PAIC compared to those of non-severe group(P＜0.001).The levels of TAT,TM and t-PAIC showed notable positive correlation with other biomarkers.TAT demonstrated the strongest positive correlation with the level of D-dimer(r=0.786,P＜0.001).Binary logistic regression analysis identified TAT(OR=1.346,P＜0.05)and t-PAIC(OR=1.128,P＜0.05)were independent risk factors in term of severe COVID-19.The combined ROC curve for TAT,TM and t-PAIC revealed high diagnostic efficacy in severe cases with the area under the curve(AUCROC)were 0.918,and the sensitivity and specificity were of 75％and 94.1％,respectively.Conclusion The results of combined measurement of TAT,TM and t-PAIC effectively demonstrates its diagnostic value in identifying severity and stratification of COVID-19 cases and may have important clinical significance for assessment of the severity and prediction of the prognosis.
