Epidemiological characteristics of Mycoplasma pneumoniae infection and diagnostic value of IL-6 and PCT detection in 1 122 pneumonia patients in Nanjing,China
10.13602/j.cnki.jcls.2024.08.13
- VernacularTitle:南京地区1122例肺炎患者肺炎支原体感染流行特点及IL-6、PCT检测的诊断价值
- Author:
Anran XIE
1
;
Zhihui DONG
;
Hongpan XU
;
Han SHEN
Author Information
1. 南京大学医学院附属鼓楼医院检验科,南京 210008
- Keywords:
Mycoplasma pneumoniae;
epidemic trends;
interleukin-6;
procalcitonin
- From:
Chinese Journal of Clinical Laboratory Science
2024;42(8):624-627
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristics and epidemic trends of Mycoplasma pneumoniae(MP)infection among the pa-tients in our hospital,and explore the diagnostic values of interleukin-6(IL-6)and procalcitonin(PCT)detection for MP infection.Methods A retrospective analysis was conducted on the test results of MP nucleic acid and clinical data,including age,gender,sam-pling date,and treatment category of the 1 122 pneumonia patients in our hospital from September 1,2022,to August 31,2023.The positive detection rate of MP nucleic acid was analyzed in different genders,ages,visit categories,and seasons.Receiver operating characteristic(ROC)curves were plotted to analyze the diagnostic value of IL-6 and PCT levels,and their ratio values in Mycoplasma pneumoniae pneumonia(MPP).Results Among the 1 122 pneumonia patients,the overall positive detection rate of MP was 24.96％.The positive detection rates of MP nucleic acid in male and female patients were 23.28％and 27.29％,respectively,with no statistical-ly significant difference(P＞0.05).The median age of MP nucleic acid-negative patients was 37 years,while that of MP nucleic acid-positive patients was 7 years,showing a statistically significant difference(P＜0.01).MP nucleic acid-positive patients were mainly concentrated in the age groups of 1 to 2 years(20.37％),3 to 5 years(25.60％),and 6 to 8 years(67.40％).The positive detection rates of MP nucleic acid among 913 inpatients and 209 outpatients were 22.45％and 35.89％,respectively,with statistically significant difference(P＜0.01).The highest MP nucleic acid positive detection rate was observed in autumn(42.47％).MP could be co-infected with five other respiratory pathogens in which human rhinovirus(HRV)was the most common(17 cases).ROC curve analysis showed that the IL-6/PCT ratio had the best diagnostic performance for MP infection in the patients with all ages,with an area under the curve(AUCROC)of 0.746,superior to IL-6 and PCT alone.For MP-susceptible patients aged 6 to 8 years,IL-6 had the highest predictive value for MP infection,with an AUCROC of 0.767.Conclusions MPP tends to be epidemic in autumn,with children aged 6 to 8 years being the main susceptible population.The IL-6/PCT ratio is expected to become an auxiliary diagnostic and prognostic evaluation indi-cator for MPP.IL-6 levels have the highest predictive value for MP infection in the susceptible population.
