Establishment of reference interval for detection indicators of thyroid function in children aged 0-15 years in Nanning area of China
10.13602/j.cnki.jcls.2024.08.11
- VernacularTitle:南宁地区0～15岁儿童甲状腺功能检测指标参考区间的建立
- Author:
Siting LI
1
;
Xiyue ZHANG
;
Dongyi ZHOU
;
Liling YI
;
Mengli FAN
;
Liuyi LU
;
Chunling ZHU
;
Qiliu PENG
Author Information
1. 广西中医药大学附属国际壮医医院检验科,南宁 530201
- Keywords:
thyroid stimulating hormone;
free thyroxine;
free triiodothyronine;
chemiluminescent microparticle immunoassay;
chil-dren;
reference interval
- From:
Chinese Journal of Clinical Laboratory Science
2024;42(8):614-618
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the reference intervals for test indicators of thyroid function,namely thyroid stimulating hormone(TSH),free thyroxine(FT4),and free triiodothyronine(FT3),in the children aged 0 to 15 years old in Nanning,China.Methods A total of 1 289 healthy children aged 0 to 15 years old who attended the Guangxi International Zhuang Medicine Hospital Affiliated with Guangxi University of Chinese Medicine from October 2018 to August 2023 were selected.The concentrations in serum TSH,FT4,and FT3 were measured by chemiluminescent microparticle immunoassay(CMIA).According to the Clinical and Laboratory Standards Institute(CLSI)EP28-A3c guideline,the nonparametric percentile method was used to establish the reference intervals for TSH,FT4,and FT3 in the children aged 0 to 15 years old in Nanning area.Results The established reference intervals were as follows:TSH(male):0 to＜1 month:0.88-7.81 μIU/mL,1 month to 15 years:0.59-5.06 μIU/mL;TSH(female):0 to＜1 month:0.93-8.42μIU/mL,1 month to 15 years:0.60-4.30 μIU/mL.FT4(male):0 to＜1 month:0.99-1.92 pg/mL,1 month to 15 years:0.86-1.33 pg/mL;FT4(female):0 to＜1 month:1.05-2.06 pg/mL,1 month to 15 years:0.85-1.37 pg/mL;FT3:0 to＜1 month:2.16-4.24 pmol/L,1 month to＜11 years:2.75-4.49 pmol/L,11 to 15 years:2.45-4.34 pmol/L.Significant differences were observed among different gender and age groups for TSH,FT4,and FT3 levels(P＜0.05).Conclusion This study successfully established the refer-ence intervals of TSH,FT4,and FT3 in the children aged 0 to 15 years old in Nanning area,which were significantly different among various gender and age groups.
