Advances in signal pathways related to pulp regeneration mediated by exosomes
10.13591/j.cnki.kqyx.2024.10.010
- VernacularTitle:由外泌体介导的牙髓再生相关信号通路研究进展
- Author:
Zirong CHEN
1
;
Hua TU
;
Leyi CHEN
;
Wen'an XU
Author Information
1. 南方医科大学口腔医学院,广东广州(510080)
- Keywords:
exosomes;
pulp regeneration;
signaling pathway;
angiogenesi
- From:
STOMATOLOGY
2024;44(10):775-779
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are a kind of extracellular vesicles,which directly stimulate target cells through receptor-mediated interaction,or exert their biological functions by transferring various bioactive molecules to target cells,playing a key role in intercellular communi-cation between cells and their microenvironment.From the perspective of tissue engineering,pulp regeneration refers to the combination of scaffolds,stem cells,and signaling factors implanted into a properly treated pulp cavity.Under the action of scaffolds and signaling factors,stem cells proliferate and differentiate to form pulp dentin-like complexes,restoring pulp function.In recent years,studies have found that p38MAPK,TGF-β/SMAD,Wnt/β-Catenin signaling pathway and some other signaling pathways are important for the se-cretion in regulating pulp regeneration,and play a key role in pulp regeneration.Therefore,this article reviews the mechanism and re-search progress of signaling pathways related to the regulation of pulp regeneration by exosomes.
