Impact of oral microbiota on radiation-induced oral mucositis:A single-arm prospective study
10.13591/j.cnki.kqyx.2024.08.008
- VernacularTitle:口腔微生物影响放射性口炎:一项单臂前瞻性研究
- Author:
Zhiyuan LU
1
;
Yimin XU
;
Mengyuan ZHOU
;
Yang LU
;
Zhihao WEI
;
Can XIAO
Author Information
1. 苏州大学附属第一医院口腔科,苏州大学放射医学与辐射防护国家重点实验室,江苏苏州(215026)
- Keywords:
oral microbiome;
head and neck tumour;
oral mucositis;
radiation therapy
- From:
STOMATOLOGY
2024;44(8):596-601
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate dynamic shifts in the oral microbiota and their association with the progression and aggravation of radiotherapy-induced oral mucositis(RIOM)in patients with head and neck malignancies undergoing radiotherapy.Methods Based on 16S rRNA gene sequencing,dynamic changes of oral microbiota in patients was analyzed.Results Firmicutes,Bacteroidetes,and Actinobacteria consistently constituted the predominant bacteria in the oral cavity.While there were no significant changes in the abso-lute abundance of microbiota,there were notable alterations in their relative richness and evenness.Analyses including CCA/RDA and Kruskal-Wallis indicated a significant increase in the proportions of Streptococcus and Lactobacillus genera in the later stages post-radio-therapy,showing statistically meaningful differences.Conclusion RIOM is associated with dysbiosis of oral microbiota.Microbial dys-biosis may aggravate the severity of RIOM.Streptococcus and Lactobacillus could be closely related to the progression of RIOM,pending further validation through animal experiments.
