Research progress of the role and application of polyunsaturated fatty acid metabolites in oral diseases

VernacularTitle:多不饱和脂肪酸代谢产物在口腔疾病中的作用及应用研究进展
Author: Huaxing XU ^{1
,

2} ; Xiaoling WEI
Author Information

1. 上海市口腔医院牙体牙髓病科,上海(200001)
2. 上海市颅颌面发育与疾病重点实验室,上海(200001)
Keywords: polyunsaturated fatty acid; periodontitis; oral disease; pulpitis; oral mucosal diseases
From: STOMATOLOGY 2024;44(7):545-550
CountryChina
Language:Chinese
Abstract: This review aims to explore research progress ofthe role and application of polyunsaturated fatty acid(PUFA)metabolites in oral diseases.We first briefly review the metabolic pathways and key enzymes of PUFAs,as well as their biological functions.Then,we discuss in detail the role of PUFA metabolites in various oral diseases,including oral mucosal diseases,periodontal diseases,dental and pulp diseases,oral cancer,and temporomandibular joint disorders(TMD).Studies have shown that PUFA metabolites play an im-portant role in regulating inflammation,immune responses,and tissue repair,and are closely involved in the development and progres-sion of oral diseases.Moreover,PUFA metabolites have potential application value in the diagnosis,treatment,and prevention of oral diseases.Therefore,research on the role and application of PUFA metabolites in oral diseases will help deepen our understanding of the pathogenesis of oral diseases and provide new ideas and methods for clinical treatment of oral diseases.