Progress and prospects of dental pulp stem cells in diabetes treatment
10.13591/j.cnki.kqyx.2024.06.010
- VernacularTitle:牙髓干细胞治疗糖尿病的研究进展
- Author:
Ailan HUANG
1
;
Peipei GUO
;
Xiaoqing LU
;
Jintao WU
;
Zehan LI
;
Xiuqing XU
;
Juan WANG
;
Lili ZHOU
Author Information
1. 南京医科大学口腔医学院口腔内科学系,江苏南京(210029)
- Keywords:
dental pulp stem cells;
diabetes mellitus;
insulin;
complication;
immunoregulation
- From:
STOMATOLOGY
2024;44(6):452-457
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus(DM)stands as a chronic metabolic ailment predominantly characterized by elevated blood glucose lev-els,stemming from either a resistance to insulin or aberrations in insulin secretion.The ensuing persistent hyperglycemia,a direct con-sequence of pancreatic β-cell devastation,acts as a catalyst for a myriad of complications,inclusive of extensive neuropathies.The dis-ease has substantial prevalence and mortality rates,underscoring the gravity of its impact on public health.Dental pulp stem cells(DPSCs)are readily obtainable,and they exhibit a profound capacity for self-renewal,multi-lineage differentiation,and vigorous pro-liferation.Remarkably,DPSCs can differentiate into pancreatic β-cells,subsequently participate in insulin secretion and play a pivotal role in immune modulation.This has achieved notable advancements in the therapeutic domain,particularly in the treatment of chronic diseases.Furthermore,DPSCs harbor the potential to mitigate symptoms in patients afflicted with type 1 diabetes.They navigate this therapeutic pathway through mechanisms that involve suppressing autoimmunity,modulating inflammatory responses,and counteracting oxidative stress.This article meticulously reviews the biological characteristics inherent to DPSCs and explores their multifaceted thera-peutic potential in addressing DM and its associated complications.Through this endeavor,the article aims to contribute to the refine-ment and enhancement of DM management strategies.
