Progress of research on the role of primary cilia in cartilage degeneration in temporomandibular joint osteoarthritis
10.13591/j.cnki.kqyx.2024.06.009
- VernacularTitle:初级纤毛在颞下颌关节骨关节炎软骨退化作用中的研究进展
- Author:
Gongchen LI
1
,
2
;
Ziyue HU
;
Yao SUN
Author Information
1. 上海牙组织修复与再生工程技术研究中心,上海(200072)
2. 同济大学附属口腔医院口腔颌面外科,上海(200072)
- Keywords:
temporomandibular joint;
osteoarthritis;
cartilage degeneration;
chondrocyte;
primary cilia
- From:
STOMATOLOGY
2024;44(6):448-451
- CountryChina
- Language:Chinese
-
Abstract:
Temporomandibular joint osteoarthritis(TMJOA)is characterized by progressive cartilage degeneration,subchondral bone remodeling,chronic inflammation in the synovial tissue and osteophyte formation.Chondrocyte apoptosis is one of the main factors of cartilage degeneration.Prevention and treatment of TMJOA can be achieved by inhibiting premature or excessive chondrocyte apoptosis.Primary cilia protruding from the surface of chondrocytes can sense mechanical stimulation and induce chondrocyte differentiation.Stud-ying the role of primary cilia in TMJOA will help us understand the pathogenesis of TMJOA and construct a reasonable and effective treatment strategy.
