An experimental study on the effect of acidity of papaverine HCl on fibrosis of the corpus cavernosum of rabbit.
- Author:
In Kyu KIM
1
;
Chung Hwan OH
;
Sae Chul KIM
;
Jae Hyung YOO
Author Information
1. Department of Urology, Chung-Ang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
papaverine HCl;
corporeal fibrosis
- MeSH:
Animals;
Fibrosis*;
Hydrogen-Ion Concentration;
Male;
Papaverine*;
Penis;
Rabbits
- From:Korean Journal of Urology
1992;33(2):325-329
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was designed to investigate whether fibrosis of the corpus cavernoum(CC) induced by repeated intracavernous injection of papaverine HCl was related to pH of the drug. Forty-eight New Zealand White rabbits weighing 2.5kg-3.0kg were divided into 4 groups of 12 animals each. Group 1 received isotonic saline. Group 2; pH 2.0 papaverine HCl. Group 3; pH 3.0 papaverine HCl and Group 4; pH 4.0 papaverine HCl. The solution (0.1ml isotonic saline or 2mg. papaverine HCl of seeh pH) was injected intracorporeally twice every week for 6 months. Every one month since beginning of the injection, 2 animals of each group were sacrificed. the penis was observed with H and E and Masson`s lrichomme stain microscopically. No sign of Fibrosis was found in the CC of the group l even after 6months of injection. However, Group 2. 3 and 4 began to show focal of diffuse thin fibrotic changes after 2 months of injection. The fibrotic changes progressed more and more in accordance with the Frequency of papaverine HCl injection. After 4 months of injection. Group 2 showed diffuse thick fibrosis whereas Group 3 and 4 showed diffuse thin or focal thick fibrosis. In conclusion, intracavernous papaverine itself seems to play a main role to induce fibrosis of CC. However, the acidity of the papaverine HCl also might be responsible to development of the fibrosis when injected repeatedly for a long period.
