Elevation of lactate dehydrogenase in Amanita oberwinkleran poisoning and prognostic analysis
10.3760/cma.j.issn.1671-0282.2024.10.014
- VernacularTitle:欧氏鹅膏中毒乳酸脱氢酶升高及预后分析
- Author:
Qingchun HE
1
;
Juan YANG
;
Min DAI
;
Shanhong PENG
;
Xiangmin LI
Author Information
1. 中南大学湘雅医院急诊科，长沙 410008
- Keywords:
A.oberwinkleran;
Poisoning;
AKI;
Lactate dehydrogenase;
Prognosis
- From:
Chinese Journal of Emergency Medicine
2024;33(10):1434-1438
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics, changes in lactate dehydrogenase (LDH) levels, and prognosis in cases of Amanita oberwinklerana poisoning.Methods:A retrospective analysis was conducted on the clinical data of 12 patients who were diagnosed with Amanita oberwinklerana poisoning at Xiangya Changde Hospital between January 2019 and December 2022. The analysis included an assessment of clinical manifestations, renal function changes, LDH levels, and patient prognosis. All statistical analyses were performed using SPSS25.0 Comparisons of ratios between groups were performed using the t test, correlation analyses were performed using scatter diagram and Pearson correlation method, P<0.05 was considered statistically significant. Results:The latency period for symptom onset ranged from 6 to 18 hours, with early symptoms primarily consisting of nausea and vomiting. Three patients developed anuria in the early stage. All patients experienced acute kidney injury (AKI) accompanied by mild liver injury. LDH levels were significantly elevated compared to other types of mushroom poisoning cases ( P < 0.01), with a mean peak value exceeding 2000 U/L. While no correlation was found between LDH levels and kidney injury severity, a positive correlation was observed between LDH levels and length of the course. All 12 patients recovered following dialysis treatment, with recovery periods ranging from 20 to 60 days. No cases of chronic renal failure or mortality were reported. Conclusions:Amanita oberwinklerana poisoning primarily causes acute renal injury. A significant elevation in LDH levels may serve as a potential marker for this type of poisoning. LDH levels did not correlate with kidney injury severity, while positively corrected with the length of the course. All patients in this study achieved good prognosis with full renal recovery.
