Predictive value of FAR, CAR and PLR in hyperlipidemic acute pancreatitis
10.3760/cma.j.issn.1671-0282.2024.10.006
- VernacularTitle:FAR、CAR和PLR对高脂血症性急性胰腺炎的预测价值
- Author:
Qiaofang WANG
1
;
Chaopeng MEI
;
Yaodong SONG
;
Yanna LIU
;
Dejian LI
;
Mengwei CUI
;
Qianqian HE
;
Huihui LI
;
Haifeng WANG
;
Changju ZHU
Author Information
1. 郑州大学第一附属医院急诊科，河南省急诊与创伤工程研究中心，河南省急诊与创伤研究医学重点实验室，郑州 450052
- Keywords:
Hyperlipidemia;
Acute pancreatitis;
Fibrinogen to albumin ratio;
Creatinine to albumin ratio;
Platelet to lymphocyte ratio;
Forecast;
Value;
Poor prognosis
- From:
Chinese Journal of Emergency Medicine
2024;33(10):1376-1382
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of fibrinogen to albumin ratio (FAR), creatinine to albumin ratio (CAR) and platelet to lymphocyte ratio (PLR) in predicting the poor prognosis of hyperlipidemic acute pancreatitis (HLAP).Methods:Clinical data of HLAP patients admitted to the hospital from January 2021 to January and December 2023 were retrospectively collected. According to the prognosis, the patients were divided into two groups: good prognosis group and poor prognosis group.The independent risk factors of HLAP in different prognostic groups were obtained by multivariate Logistic regression analysis. Receiver operating characteristic (ROC) curves were plotted to evaluate the prognostic value of FAR, CAR and PLR alone and in combination.Results:A total of 118 patients with HLAP were included, including 69 patients with good prognosis and 49 patients with poor prognosis.The difference of heart rate, lymphocyte, triglyceride, albumin, creatinine, urea nitrogen, blood calcium, blood glucose, C-reactive protein, procalcitonin, fibrinogen, FAR, CAR, PLR, Bedside indicator of acute pancreatitis Severity score, Acute Physiology and Chronic Health status score, hospitalization time assessment between the two groups was statistically significant ( P<0.05). Multivariate Logistic regression analysis showed that FAR (odds ratio ( OR) = 25.949, 95% confidence interval (95% CI):3.190 ~ 211.080, P = 0.002), CAR ( OR = 1.453, 95% CI:1.095 ~ 1.928, P = 0.010) and PLR ( OR = 1.005, 95% CI: 1.001 ~ 1.009, P = 0.020) were independent risk factors for poor prognosis in HLAP patients. ROC curve analysis showed that the area under the ROC curve (AUC) of FAR, CAR and PLR to predict poor prognosis of HLAP patients were 0.823, 0.781 and 0.652, respectively.The AUC of FAR combined with CAR, FAR combined with PLR and CAR combined with PLR were 0.840, 0.845 and 0.849, respectively.The combined ability of FAR, CAR and PLR to predict poor prognosis in HLAP patients was (AUC=0.875,95% CI:0.814 ~ 0.937). When the cut-off value was 0.387, the sensitivity was 83.7%, and the specificity was 79.7%. Conclusions:The prognostic value of FAR, CAR and PLR in HLAP patients is better than that of single or pairwise combination.
