Principal component analysis of venous to arterial CO 2 content gap in septic shock patients
10.3760/cma.j.issn.1671-0282.2024.04.005
- VernacularTitle:感染性休克患者静动脉CO 2含量差的主成分分析
- Author:
Xixi WAN
1
;
Ruiting LIU
;
Yuanyuan LI
;
Li WENG
;
Jinmin PENG
;
Bin DU
Author Information
1. 中国医学科学院北京协和医学院 北京协和医院内科重症监护室，北京 100730
- Keywords:
Septic shock;
Venous-to-arterial carbon dioxide content diference;
Venous-to-arterial carbon dioxide tension diference;
Principal component analysis;
Shoc
- From:
Chinese Journal of Emergency Medicine
2024;33(4):480-484
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The principal components (PC) of venous-to-arterial carbon dioxide content diference [C(v-a)CO 2] were extraceted in septic shock patients, in orter to compare the contribution of the principal components to C(v-a)CO 2. Methods:Septic shock patients monitored by Swan Ganz floating catheter in the Medical Intensive Care Unit of Peking Union Medical College Hospital were included in the retrospective study. All pairs of arterial and mixed-venous blood gases within 1 h before and after a flood challenge were included in the analyses. The principal component method was used to extract the components of C(v-a)CO 2. Spearman correlation analysis was used to evaluate the correlation between the components and C(v-a)CO 2, and the correlation between the components and cardiac output. The differences of the components beween the 28-day survival group and 28-day death group were analyzed by univariate analysis. Results:A total of 504 pairs of blood gases in 104 septic shock patients were included in the analyses. The median age of patients was 62 years ( IQR, 48 to 71), and 59.6% (62/104) were men. Four principal components were extracted and the components account for 77.7% of variance. PC1 included PaO 2, PvO 2, SaO 2 and SvO 2. PC2 included pHa and pHv. PC3 included Hb and Hct. PC4 included PaCO 2 and PvCO 2. There was a significant difference in PC4 between the two group. PC4 could weakly predict the 28-day death (AUROC 0.634, 95% CI 0.527-0.741, P=0.015). Conclusions:In patients with infectious shock, arteriovenous [C(v-a)CO 2] consists of principal components of four dimensions: oxygenation, pH, Hb, and CO 2 partial pressure difference.Arterial CO 2 partial pressure difference [P(v-a)CO2] weakly predicts 28-d morbidity and mortality.
