Research progress in and applications of influenza virus pseudoviruses
10.7644/j.issn.1674-9960.2024.11.012
- VernacularTitle:流感病毒假病毒研究进展
- Author:
Wanlu ZHU
1
,
2
;
Jun ZHANG
;
He XIAO
Author Information
1. 军事科学院军事医学研究院国家安全特许药物全国重点实验室,北京 100850
2. 河南大学抗体药物开发技术国家地方联合工程实验室,河南开封 475004
- Keywords:
influenza virus;
pseudovirus;
research progress
- From:
Military Medical Sciences
2024;48(11):869-873
- CountryChina
- Language:Chinese
-
Abstract:
Since emergence,the influenza virus has triggered numerous global pandemics and claimed more than ten million lives.This virus poses not only a severe threat to human life and health,but significant challenges to global economy and public health.The research on highly pathogenic influenza virus strains(such as H5 and H7)necessitates the use of biosafety level 3 laboratories,which significantly escalates the experimental risks and costs.The pseudovirus technology,as a relatively safe and effective research technique,has been applied in the studies of various high-risk viruses.Thanks to constant research and refinement,the pseudovirus technology for the influenza virus currently boasts such advantages as user-friendliness and good safety,and has been extensively used antibody neutralization and screening of antiviral drugs.This article reviews the research progress in the pseudovirus technology for the influenza virus.
