Ionizing radiation damage:mechanisms of action and drug strategies
10.7644/j.issn.1674-9960.2024.11.011
- VernacularTitle:电离辐射损伤的作用机制与药物策略
- Author:
Qinghua YU
1
,
2
;
Zhen LI
;
Tingkun ZHAO
;
Zixia TANG
;
Mei LV
;
Litao WANG
Author Information
1. 山东第二医科大学药学院,山东潍坊 261053
2. 济宁医学院药学院,山东日照 276826
- Keywords:
ionizing radiation;
radiation damage;
mechanism of action;
pharmacological strategies;
radiation protec-tion
- From:
Military Medical Sciences
2024;48(11):863-868
- CountryChina
- Language:Chinese
-
Abstract:
With wide applications of radiation therapy in the treatment of cancer and other diseases and amid the in-creasing concerns about global nuclear safety,the research and development of drugs against radiation damage has become a hot spot.Thanks to its high energy properties,ionizing radiation can not only directly damage cell DNA through targeted effects,but also indirectly affect the cell environment through non-targeted effects,leading to cell dysfunction and even death.In this paper,the mechanism of ionizing radiation damage was analyzed,and the mechanisms of action and clinical applications of four types of anti-radiation drugs,namely,antioxidant,apoptosis inhibitor,cytokine and natural radiation protection agent were discussed.These drugs have huge implications for alleviating the targeted and non-targeted effects caused by ionizing radiation.
