Genetic diversity and recombination events of human infections with Sapovirus
10.7644/j.issn.1674-9960.2024.10.003
- VernacularTitle:人感染札如病毒的遗传多样性与重组事件分析
- Author:
Wanqiu LIU
1
,
2
,
3
;
Mingda HU
;
Xiaofeng HU
;
Hongguang REN
;
Xin WANG
;
Yaqing HE
Author Information
1. 南华大学公共卫生学院,湖南衡阳 421001
2. 军事科学院军事医学研究院,北京 100071
3. 深圳市疾病预防控制中心,病原微生物研究所,广东 深圳 518055
- Keywords:
Sapovirus;
phylogenetic tree;
genetic recombination;
genetic diversity;
molecular evolution
- From:
Military Medical Sciences
2024;48(10):737-743
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic characteristics and recombination of human-infected sapoviruses(SaVs)worldwide using bioinformatics.Methods The complete genome sequences of SaVs were downloaded from the National Center for Biotechnology Information(NCBI)while high-quality complete genomes were retained for analysis.Molecular phylogenetic trees of SaVs were constructed to analyze their genetic characteristics,followed by recombination analysis of human-infected SaV strains genetype Ⅰ,Ⅱ,Ⅳ,and V(G Ⅰ,G Ⅱ,GⅣ,and GⅤ)with recombination analysis software.Results SaVs exhibited substantial genetic diversity worldwide and infected a wide range of hosts.Human-associated SaVs included G Ⅰ,G Ⅱ,GⅣ,and GⅤ,with GⅤ shared between human and swine hosts.Genetype recombination analysis of SaVs revealed a high frequency of recombination in SaV G Ⅱ strains that involved diverse hosts in the field of SaV G V strains.Recombination breakpoints of the virus were concentrated in the major viral proteins 1(VP1)and minor viral proteins 2(VP2).Conclusion Based on systematic analysis of the genetic characteristics of human-infected SaVs,the genotype distribution and prevalence of SaVs are investigated,the recombination patterns of SaV revealed,and its genetic dynamics highlighted.These findings can offer insights into epidemiological trends of viruses and help devise effective prevention and control strategies.
