Research progress in impact of bodily damage on gut microecology induced by exposure to high-altitude hypoxic environments
10.7644/j.issn.1674-9960.2024.09.009
- VernacularTitle:高原低氧环境暴露所致机体损伤对肠道微生态的影响及其关联性研究进展
- Author:
Yufan DING
1
;
Yating WANG
;
Weili LIU
;
Zhiqiang SHEN
Author Information
1. 军事科学院军事医学研究院,天津 300050
- Keywords:
high-altitude environment;
hypoxia;
gut microecology;
metabolites
- From:
Military Medical Sciences
2024;48(9):690-694
- CountryChina
- Language:Chinese
-
Abstract:
A high-altitude environment is characterized by low oxygen levels,low pressure,and low temperatures.Exposure to the plateau environment often causes damage to the body,leading to the occurrence of acute mountain sickness/chronic mountain sickness(AMS/CMS).Research indicates that acute or chronic exposure to the special environment can result in overall organ dysfunctions,such as those in the heart and gastrointestinal tract.The damage to the body caused by exposure to the plateau environment is closely related to acute and chronic hypoxia.Physiological maladjustment or disease is usually accompanied by changes in the structure of the gut microbiota.There have been reports on the correlations between the gut microbiota and bodily harm caused by high-altitude exposure.However,the specific types of bacteria involved and the mechanisms of action are still under investigation.This article reviews the intestinal tissue damage caused by low oxygen levels,immune activation,changes in microbial community structure,and differential metabolic products.The association and underlying mechanisms between bodily harm due to high-altitude exposure and the intestinal microbiota are also explored in hopes of stimulating new lines of thought related to the prevention and treatment of bodily harm caused by exposure to the plateau environment.
