Regulatory effects of psilocybin on social behavior in mice
10.7644/j.issn.1674-9960.2024.06.002
- VernacularTitle:裸盖菇素对小鼠社交行为调控作用研究
- Author:
Xin LEI
1
;
Shen LI
;
Yufei WANG
;
Wenlong XIA
;
Yan WU
;
Zhe ZHAO
;
Haitao WU
Author Information
1. 青岛大学基础医学院,山东青岛 266071
- Keywords:
psilocybin;
prosocial behavior;
three-chamber test;
two-chamber test
- From:
Military Medical Sciences
2024;48(6):407-413
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the regulatory effects of psilocybin on social behavior of male C57BL/6J mice.Methods Adult male C57BL/6J mice were intraperitoneally injected with psilocybin(0.2,1 and 5 mg/kg,i.p.),and the effects of psilocybin on prosocial behavior were evaluated by the three-chamber test.Stressed mice undergoing chronic social defeat stress(CSDS)were given acute intraperitoneal injection of psilocybin(1 mg/kg)to evaluate the moderation of social novelty preference behavior using the modified two-chamber test.Results Intraperitoneal injection of psilocybin(1 mg/kg)promoted prosocial behavior and prolonged social time(P＜0.01),while intraperitoneal injection of psilocybin(0.2 mg/kg)had no apparent effect on the prosocial behavior of mice,and intraperitoneal injection of psilocybin(5 mg/kg)inhibited prosocial behavior before promoting it.Further studies showed that intraperitoneal injection of psilocybin(1 mg/kg)increased the social novelty exploration time in stressed mice undergoing CSDS.Conclusion This study shows that 1 mg/kg dose of psilocybin can promote the prosocial behavior in mice,and potentially ameliorate the deficit of social novelty preference behavior in CSDS mice.
