Research progress in analysis and detection techniques,toxicity mechanism,and detoxification countermeasures of Abrin
10.7644/j.issn.1674-9960.2024.04.008
- VernacularTitle:相思子毒素的分析检测技术及毒性机制与解毒对抗措施研究进展
- Author:
Lan XIAO
1
,
2
;
Chuang WANG
;
Jia LIU
;
Luyao LIU
;
Lei GUO
;
Li TANG
Author Information
1. 中央民族大学药学院民族医药教育部重点实验室,北京 100081
2. 军事科学院军事医学研究院毒物分析实验室,北京 100850
- Keywords:
Abrin;
analysis and detection;
toxicity mechanism;
detoxification countermeasures
- From:
Military Medical Sciences
2024;48(4):294-302
- CountryChina
- Language:Chinese
-
Abstract:
Abrin,the most lethal plant-derived toxin known today,has attracted widespread attention from both the International Chemical Weapon Convention and the Biological and Toxin Weapons Convention.There is an urgent demand for the development of efficient detection and detoxification countermeasures against Abrin to adress its potential threats to human health and public safety.This review,based on clustering analysis of literature and on knowledge of the structures of various subtypes of Abrin,provides an overview of the analysis and detection techniques,the mechanism of toxicity,and detoxification countermeasures against Abrin.It concludes with an examination of the challenges and emerging trends in this field.The main analysis and detection techniques of Abrin include affinity-based analysis,physico-chemical-based analysis,and activity-based detection techniques.The challenges and developments in this field are also outlined.There is a pressing need to establish sensitive,specific,and accurate methods of measurement that are tailored to the structure and activity of Abrin in order to precisely assess and mitigate the toxin threat.Unfortunately,no effective antidotes have been deployed so far,with medical treatments confined to symptomatic care.Research and development of neutralizing antibodies remain stands as the most promising strategy for counteracting Abrin intoxication.
