Contrast analysis of oxaliplatin adverse reactions though different intravenous injection ways

VernacularTitle:奥沙利铂不同静脉输注途径的不良反应对比分析
Author: Xinhua ZHOU ¹ ; Yisu WANG ; Haiyu LIN ; Kechao LYU ; Xia LI
Author Information

1. 325007 温州医科大学附属第二医院血液肿瘤科
Keywords: Catheterization; CVC; Peripheralvein; Oxaliplatin; Toxic action
From: Chinese Journal of Modern Nursing 2015;21(6):719-721
CountryChina
Language:Chinese
Abstract: Objective To compare the adverse reaction′s incidence of oxaliplatin with three different injection ways , to explore the most appropriate infusion .Methods A total of 90 patients were randomly divided into 3 groups averagely: peripheral vein ( PV ) group, central venous catheterization ( CVC ) group and peripherally inserted central catheter ( PICC) group.The occurrence rate and degree of adverse reaction were compared among groups including peripheral neuritis , blood system , digestive system toxicity .Results The occurrence rates of peripheral neuritis were 37.50%, 21.43%, 10.00% in the PV group, CVC group and PICC group, and the difference was statistically significant (χ2 =6.628,P<0.05).The occurrence rates of toxic action of blood system and digestive system were respectively 53.13%, 53.57%, 50.00%and 78.13%, 92.86%, 73.33%in the PV group, CVC group and PICC group with no statistical difference (χ2 =0.090, 3.892,respectively;P>0.05).Conclusions The best method of oxaliplatin infusion among these three ways is PICC, followed by CVC, and PV is not recommended.