Effect of pulsed radiofrequency combined with nerve block on SF-MPQ score,levels of serum substance P and IL-1β in patients with refractory postherpetic neuralgia
10.3969/j.issn.1008-794X.2024.11.008
- VernacularTitle:脉冲射频联合神经阻滞治疗对顽固性带状疱疹后神经痛患者SF-MPQ评分及血清P物质、IL-1β水平的影响
- Author:
Baofu LI
1
;
Bing LIU
;
Chunman WANG
;
Lin LI
;
Qian GAO
Author Information
1. 053000 河北衡水 衡水市人民医院(哈励逊国际和平医院)疼痛科
- Keywords:
postherpetic neuralgia;
pulsed radiofrequency;
nerve block;
short-form of McGill pain questionnaire;
substance P;
interleukin-6;
quality of life
- From:
Journal of Interventional Radiology
2024;33(11):1197-1202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of pulsed radiofrequency combined with nerve block on the score of short-form of McGill pain questionnaire(SF-MPQ)and the levels of serum substance P(SP)and interleukin(IL)-1β in patients with refractory postherpetic neuralgia(PHN).Methods A total of 219 patients with PHN,who were admitted to the Hengshui Municipal People's Hospital of China between April 2021 and April 2022,were collected as the objects of study.Using random number table method,the patients were divided into group A(n=73,receiving pulsed radiofrequency therapy),group B(n=73,receiving nerve block therapy),and group C(n=73,receiving pulsed radiofrequency combined with nerve block therapy).The SF-MPQ score,levels of serum SP and IL-1β,degree of anxiety and depression,and quality of life were compared between each other among the three groups.Results Among the 219 patients with PHN,6 patients were excluded from this study due to losing in touch or due to receiving other therapies,and finally group A had 71 patients,group B had 70 patients,and group C had 72 patients.At 7 d after treatment(AT7),30 d after treatment(AT30)and 90 d after treatment(AT90),in group C the scores of pain rating index(PRI),visual analogue scale(VAS)and present pain intensity(PPI)were obviously lower than those in group A and group B(P＜0.05),the levels of serum SP and IL-1β were strikingly lower than those in group A and group B(P＜0.05),and the scores of patient health questionnaire-9(PHQ9),generalized anxiety disorder 7-item(DAG7)and Generic Quality of Life Inventory 74(GQOL-74)were remarkably lower than those in group A and group B(P＜0.05).Conclusion Pulsed radiofrequency combined with nerve block can effectively reduce the pain degree and the serum SP and IL-1β levels,relieve the degree of anxiety and depression in patients with refractory PHN,which can improve the quality of life.
