Nursing effect of acute rejection for 10 liver transplant patients with mesenchymal stem cells therapy
10.3760/j.issn.1674-2907.2015.04.017
- VernacularTitle:10例间充质干细胞治疗肝移植术后急性排斥反应的护理效果
- Author:
Jingru CHU
1
;
Ying YANG
;
Ming SHI
;
Qiong LIU
;
Dan HAN
;
Zhenwen LIU
Author Information
1. 100039 北京，解放军第三〇二医院肝胆外科二中心
- Keywords:
Liver transplantation;
Nursing;
Mesenchymal stem cells;
Acute rejection
- From:
Chinese Journal of Modern Nursing
2015;21(4):420-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical nursing for acute liver allograft rejection with mesenchymal stem cells ( MSC ) therapy. Methods A total of 10 patients, who underwent the allogenic orthotopic liver transplantation in our center and suffered acute rejection, were enrolled during 2006 to 2012 and investigated by regression analysis. We regulated nursing procedure and observed clinical reaction during the procedure of MSC transfusion. Results The self-rating anxiety scale ( SAS) scores for the patients in pre- and post-MSC transfusion period were (52.6 ±9.4) and (40.3 ±8.2), respectively (t=3.118,P<0.01). The sleep time were prolonged from pre-MSC transfusion ( 6. 3 ± 0. 7 ) hrs averagely to ( 7. 6 ± 0. 9 ) hrs ( t =-3.606,P < 0. 01). The blood pressure also improved after transfusion (P < 0. 05). In addition, the subjective symptoms were improved different degrees for all patients (P<0. 05), and no obvious side effects was found. Conclusions It benefits patients′ psychological state, side effects and treatment effect if attention and specification of nursing process were paid for the patients after liver transplantation with mesenchymal stem cell transfusion.
