Efficacy and safety of ozone therapy for lumbar disc herniation:a meta-analysis based on a randomized control and systematic review
10.3969/j.issn.1008-794X.2024.07.009
- VernacularTitle:臭氧疗法治疗腰椎间盘突出症的疗效与安全性:一项基于随机对照的Meta分析和系统综述
- Author:
Feihong MA
1
;
Zhouli FENG
;
Tianying JI
;
Zhijing SONG
;
Yang LI
;
Rui CHANG
;
Jianguo WANG
;
Jianmin WU
Author Information
1. 730000 甘肃兰州甘肃中医药大学附属医院康复骨科
- Keywords:
ozone therapy;
lumbar disc herniation;
systematic review;
meta-analysis
- From:
Journal of Interventional Radiology
2024;33(7):745-752
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of ozone injection therapy for lumbar disc hemiation(LDH).Methods A computerized retrieval of academic papers concerning the randomized controlled trial(RCT)on ozone injection therapy for LDH from the databases of Embase,PubMed,Cochrane library and Web of science was conducted.The retrieval time period was from the establishment of the database to February 2023.The literature retrieval,screening,and data extraction were independently performed by two researchers.Cochrane bias risk assessment tool was used to assess the quality of the included literature.Stata 17.0 software was used to make meta-analysis.Results A total of 9 RCTs including 702 patients were finally included in this study.The results of meta-analysis showed that compared with radiofrequency thermocoagulation,percutaneous rotation and other treatments for LDH,the combination use of ozone injection could signifiicantly improve the effective rate based on Macnab efficacy evaluation criteria(RR=1.097,95％CI:1.038～1.159,P=0.001)and the excellent rate(RR=1.185～95％CI:1.074～1.309,P=0.001),and decrease the visual analog scale(VAS)pain score(WMD=-0.810～95％CI:-1.205～-0.414,P=0.000),and the differences in the above indexes were statistically significant.Conclusion Compared with the simple use of radiofrequency thermocoagulation,percutaneous rotation,and other treatment for LDH,the combination use of ozone injection therapy can significantly improve the effective rate and excellent rate based on Macnab efficacy evaluation criteria,decrease VAS score,with a high clinical safety.Limited by the quantity and quality of the original studies included in this study,the above conclusions need to be further verified by multi-center,large-sample and high-quality studies.
