Changes in diffusion tensor image analysis along the pervascular space index during aging
10.16098/j.issn.0529-1356.2024.04.017
- VernacularTitle:衰老过程中沿血管周围间隙弥散张量成像分析指数的改变
- Author:
Chen-Ye HUANG
1
;
Xiang-Jun LI
;
Dao-Jun XIE
Author Information
1. 安徽中医药大学第一临床医学院,合肥 230031
- Keywords:
Aging;
Glymphatic system;
Diffusion tensor image analysis along the perivascular space;
Human
- From:
Acta Anatomica Sinica
2024;55(4):501-507
- CountryChina
- Language:Chinese
-
Abstract:
Objective To calculate the diffusion tensor image analysis along the perivascular space(DTI-ALPS)index,evaluate the function of the glymphatic system,observe the changes in the DTI-ALPS index during the aging process,and find the relationship between the DTI-ALPS index and correlates of certain executive functions that reflect mental flexibility,based on DTI-ALPS.Methods The FSL toolbox was used to extract the DTI-ALPS index of the dominant hemisphere of the brain of adult subjects in the NKI Rockland Sample data set,and the correlations between the DTI-ALPS index and age and design fluency practical accuracy were analyzed,respectively.Differences in DTI-ALPS index among different age groups and the mediating effect of DTI-ALPS index between age and design fluency practical accuracy were analyzed.Results The DTI-ALPS index was negatively correlated with age(r=-0.288,P＜0.001),but there was a local peak of recovery in the 60-69 age group(P＜0.01).The DTI-ALPS index was positively correlated with the design fluency practical accuracy(r=0.258,P=0.001).The mediating effect of DTI-ALPS index between age and design fluency practical accuracy was statistically significant(P＜0.05),and the mediating effect accounted for 22.1％of the total effect.Conclusion The DTI-ALPS index showed an overall downward trend during the aging process,but there is a local peak of recovery in the 60-69 age group.At the same time,the DTI-ALPS index might be related to certain executive functions that could reflect thinking flexibility.
