Correlation between inflammatory response in the neurovascular unit and autophagy after cerebral infarction
10.16098/j.issn.0529-1356.2024.04.005
- VernacularTitle:脑梗死后神经血管单元炎性反应与自噬的相关性
- Author:
Li-Na TANG
1
,
2
;
Zhi-Cheng LU
;
Sheng-Long MO
;
Cheng-Min YANG
;
Chong-Dong JIAN
;
Jing-Wei SHANG
Author Information
1. 右江民族医学院研究生学院,广西百色 533000
2. 右江民族医学院附属医院神经内科,广西百色 533000
- Keywords:
Cerebral infarction;
Neurovascular unit;
Inflammatory response;
Autophagy
- From:
Acta Anatomica Sinica
2024;55(4):407-413
- CountryChina
- Language:Chinese
-
Abstract:
With the improvement of China's socioeconomic status,the issue of aging has become increasingly prominent,making cerebral infarction a common disease among the elderly.In recent years,research on cerebral infarction has gradually deepened,shifting focus from merely protecting and repairing neurons to emphasizing the complex interplay between inflammatory response and autophagy in the brain vascular unit,covering various aspects such as the blood-brain barrier,astrocytes,microglia,and autophagy.This shift in research direction has provided us with a profound understanding of the mechanisms underlying cerebral infarction,offering strong support for innovative future treatment strategies.In this review,we delved into the importance of the interplay between inflammatory response and autophagy in the pathogenesis of cerebral infarction,emphasized the intricate interactions among these biological components,which might lay the groundwork for more effective managements and treatments of cerebral infarction.By comprehensively reviewing existing literatures,we proposed future research directions,aiming to provide more scientific and systematic guidance for the clinical management and treatment of cerebral infarction.
