Research progress on inflammatory mechanism and treatment in aneurysmal subarachnoid hemorrhage
10.11855/j.issn.0577-7402.1420.2024.0604
- VernacularTitle:动脉瘤性蛛网膜下隙出血的炎症机制与治疗研究进展
- Author:
Ming ZHANG
1
;
Xiao-Wei SONG
;
Xiao-Kui GAN
;
Yi-Ming FANG
;
Bao-Sheng HUANG
Author Information
1. 南京医科大学附属逸夫医院神经外科,江苏 南京 210016
- Keywords:
subarachnoid hemorrhage;
inflammatory pathogenesis;
therapy;
outcome
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(11):1336-1342
- CountryChina
- Language:Chinese
-
Abstract:
Aneurysmal subarachnoid hemorrhage(aSAH),primarily caused by the rupture of intracranial aneurysms with bleeding into the subarachnoid space,is an acute neurological disease associated with high disability and mortality.Brain injury after aSAH results from a combination of injury mechanisms,with early brain injury(EBI)occurring within 72 hours post-onset,laying the foundation for subsequent pathophysiological changes in the brain and poor prognosis of patients.Among them,the brain immunoinflammatory response,involving the interaction of various immune cells and active substances,plays a significant role in post-aSAH EBI,and is related to delayed brain injury and long-term prognosis.Systemic inflammatory response following aSAH can also affect the prognosis and outcome of patients.This review summarizes the role of local and systemic immune inflammatory responses in the occurrence and progression of aSAH,as well as the research progress on related inflammatory biomarkers and therapeutic prospects,aiming to provide a theoretical reference for new treatment for aSAH.
