The clicicopathological observations and detection of human papillomavirus in Koreans with Bowen"s disease.
- Author:
Young Gull KIM
;
Kwang Hyun CHO
;
Chul Woo KIM
- Publication Type:In Vitro ; Original Article
- Keywords:
HLA-DR antigen;
melanocyte;
recombinant IFN-r
- MeSH:
Culture Media;
Epidermis;
HLA-DR Antigens;
Humans*;
Interleukin-1;
Melanins;
Melanocytes;
Research Personnel;
Skin;
Skin Diseases
- From:Korean Journal of Dermatology
1993;31(3):349-358
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The main function of melanocyte is known to proiect the skin from hazardous sun-light. But, some investigators have claimed lately that melanocytes are also related to the immunologic role in the epidermis becauase these cells produce IL-1 activity and IL-lb convertase activity, in vitro. OBJECTIVE: Our purposee were to investigate the effects of rIFN-b on the proliferation of melanocytes, melanin content, and the expression of HLA-DR aritign on melanocytes after a rIFN-y exposure. MEHTODS: The number of melanocytes, the melanin content, and the expression of HLA-DR antigen were evaluated on culturect human melanocytes according to a time sequence and various concentrations of rIFN-y. RESULTS: Antiproliferative activity on melanocytes was dependent on the exposure time and the concentration of rIFN-r. According to the exposure time and the concentration of rIFN-r, melanogenic activity was inhibited or stimulated, Normal melanocytes didnt express HLA-DR antigen, but when normal melanocytes were exposed to rIFN-r, the expression of HLA-DR antigen increased in a timeand concentration-dependent fashion. After the removal of rIFN-r fiom the culture media the expression of HLA-DR antigen on melanocytes also disappeared. CONCLUSION: In our study, melanocytes seem to be related to the irnmunologic role in the epidermis because these cells expressed HLA-DR antigen after rIFN-r exposue and we think that study could help to investigate between melanocytes and immunalogic mechanisms in various inflammatory skin diseases.
