Research progress on the impact of lipid metabolism on endometrial receptivity and embryo implantation
10.11855/j.issn.0577-7402.1066.2024.0514
- VernacularTitle:脂质代谢对子宫内膜容受性及胚胎着床影响的研究进展
- Author:
Li-Na MA
1
,
2
;
Ying QIN
;
Ke-Hua WANG
;
Cong-Hui PANG
;
Li-Ge LU
;
Wen-Xian YUAN
;
Duo-Jia ZHANG
;
Xiao-Ke WU
Author Information
1. 山东中医药大学附属医院产科,山东济南 250014
2. 山东中医药大学博士后流动站,山东济南 250000
- Keywords:
lipid metabolism;
endometrial receptivity;
embryo implantation;
prostaglandins;
endocannabinoids
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(9):1088-1093
- CountryChina
- Language:Chinese
-
Abstract:
Lipids,including fats(triglycerides)and lipoids(phospholipids and sterols),not only serve as an energy source for the body but also play a pivotal role throughout the reproductive process,particularly in the establishment and maintenance of early pregnancy.This encompasses the regulate of early embryonic development and uterine tolerance,and the facilitation of embryo implantation.Given the diversity of lipids,this review focuses on extensively studied lipid mediators such as polyunsaturated fatty acids,endocannabinoids,prostaglandins,lysophosphatidic acid,sphingolipids and steroid hormones.It systematically elaborates on the regulatory effects of fatty acid,phospholipid,and cholesterol metabolism on the formation of endometrial receptivity and embryo implantation,as well as the potential underlying mechanisms.The review aims to provide new insights and feasible intervention approaches for predicting and improving the outcomes of natural pregnancy and/or assisted reproductive technology.
