Research progress on the relation between gut microbiome-gut-brain axis and post-stroke cognitive impairment

VernacularTitle:肠道微生物-肠-脑轴与卒中后认知障碍的相关性研究进展
Author: Zhuan LYU ¹ ; Ya-Min WANG ; Rui-Dong LIU ; Kai-Qi SU ; Ming-Li WU ; Ming ZHANG ; Jing GAO ; Xiao-Dong FENG
Author Information

1. 河南中医药大学第一附属医院康复中心,河南郑州 450000
Keywords: post-stroke cognitive impairment; gut microbiome-gut-brain axis; blood brain barrier; neuroinflammation
From: Medical Journal of Chinese People's Liberation Army 2024;49(9):1073-1079
CountryChina
Language:Chinese
Abstract: Post-stroke cognitive impairment(PSCI)is a prevalent functional impairments following stroke that seriously affects patients'quality of life and daily activities.Studies indicate a close relationship between intestinal microflora dysbiosis and central nervous system diseases.Intestinal microflora profoundly impacts on human physiological health,contributing to the stability of nervous,metabolic and immune systems through regulation of the gut-brain axis.An increasing number of studies confirmed the important role of the gut microbiome-gut-brain axis in the occurrence and development of stroke and its associated PSCI,and regulation of microbiome-gut-brain could be potential target to treatment of PSCI.This review summarizes research progress on gut microbiome-gut-brain axis and PSCI to provide a reference for exploration of related mechanisms and clinical prevention and treatment strategies.