Correlation between the level of NT-proBNP and cardiorespiratory fitness of individuals following acute high altitude exposure
10.11855/j.issn.0577-7402.1273.2024.0717
- VernacularTitle:NT-proBNP与急进高原人群心肺适能的相关性分析
- Author:
Ping-Ping LI
1
;
Xiao-Wei YE
;
Jie YANG
;
Zhe-Xue QIN
;
Shi-Zhu BIAN
;
Ji-Hang ZHANG
;
Xu-Bin GAO
;
Meng-Jia SUN
;
Zhen LIU
;
Hai-Lin LYU
;
Qian-Yu JIA
;
Yuan-Qi YANG
;
Bing-Jie YANG
;
Lan HUANG
Author Information
1. 陆军军医大学第二附属医院心血管内科/陆军军医大学全军高原医学临床重点专科,重庆 400037
- Keywords:
cardiorespiratory fitness;
high altitude;
N-terminal pro-Brain natriuretic peptide;
cardiopulmonary exercise test
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(9):998-1003
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the level of N-terminal pro-Brain natriuretic peptide(NT-proBNP)and cardiorespiratory fitness following acute exposure to high altitude.Methods Forty-six subjects were recruited from the Second Affiliated Hospital of Army Medical University in June 2022,including 19 males and 27 females.After completing cardiopulmonary exercise test(CPET),serological detection of myocardial cell-related markers,and multiple metabolites at a plain altitude(300 meters above sea level),all subjects flew to a high-altitude location(3900 meters above sea level).Biomarker testing and CPET were repeated on the second and third days after arrival at high altitude.Changes in serum biomarker and key CPET indicators before and after rapid ascent to high altitude were compared,and the correlation between serum levels of various myocardial cell-related markers and metabolites and high altitude cardiorespiratory fitness was analyzed.Results Compared with the plain altitude,there was a significant decrease in maximal oxygen uptake after rapid ascent to high altitude[(25.41±6.20)ml/(kg.min)vs.(30.17±5.01)ml/(kg.min),P<0.001].Serum levels of NT-proBNP,Epinephrine(E),plasma renin activity(PRA),angiotensin Ⅱ(Ang Ⅱ),angiotensin-converting enzyme 2(ACE2)and leptin(LEP)significantly increased,with all differences being statistically significant(P<0.05)after acute high altitude exposure.In contrast,no statistically significant differences were observed for creatine kinase MB(CK-MB),cardiac troponin I(cTnI),myoglobin(Myo)and norepinephrine(NE)(P>0.05).Correlation analysis showed a significant negative correlation between NT-proBNP at plain altitude(r=-0.768,P<0.001)and at high altitude(r=-0.791,P<0.001)with maximal oxygen uptake at high altitude.Multivariate linear regression analysis indicated that maximal oxygen uptake at plain altitude(t=2.069,P=0.045),NT-proBNP at plain altitude(t=-2.436,P=0.020)and at high altitude(t=-3.578,P=0.001)were independent influencing factors of cardiorespiratory fitness at high altitude.Conclusion Cardiorespiratory fitness significantly decreases after rapid ascent to high altitude,and the baseline NT-proBNP level at plain altitude is closely related to cardiorespiratory fitness at high altitude,making it a potential predictor indicator for high altitude cardiorespiratory fitness.
