Advances in the study of linezolid-related adverse reactions of blood and metabolic system
10.11855/j.issn.0577-7402.1083.2024.0124
- VernacularTitle:利奈唑胺相关血液及代谢系统不良反应研究进展
- Author:
Jun-Qiang GOU
1
,
2
;
Qian LI
;
Dong-Feng YIN
;
Xiao-Feng WANG
Author Information
1. 石河子大学药学院,新疆石河子 832003
2. 新疆军区总医院药剂科,新疆乌鲁木齐 830000
- Keywords:
linezolid;
blood;
metabolism;
adverse reaction;
individualized drug administration
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(8):965-972
- CountryChina
- Language:Chinese
-
Abstract:
Linezolid,a fully synthetic oxazolidinone antibiotic,is mainly used to treat severe infections caused by Gram-positive drug-resistant bacteria.In recent years,with the rise in drug-resistant bacteria,the clinical utilization rate of linezolid and the incidence of linezolid-related adverse reactions in the hematological system and metabolic system have increased.The main adverse reactions include thrombocytopenia,anemia and lactic acidosis.Studies have shown that the causes of adverse reactions in linezolid-induced hematological system and metabolic system are diverse,and the mechanisms are not fully elucidated.In this review,the pharmacokinetic characteristics,mechanism of adverse reactions,risk factors,as well as preventive measures and individualized drug administration strategies of linezolid in vivo were discussed based on literature reports at home and abroad,aiming to provide references for clinical prevention and treatment of linezolid-related adverse reactions of hematological system and metabolic system.
