Application of smart responsive materials in the precise repair of osteonecrosis of the femoral head
10.11855/j.issn.0577-7402.0673.2023.1010
- VernacularTitle:智能响应性材料在股骨头坏死精准修复中的应用
- Author:
Hao CHEN
1
;
Hong-Zhong XI
;
Peng XUE
;
Shuai HE
;
Xiao-Xue TAN
;
Guang-Quan SUN
;
Xin LIU
;
Xiao-Hong JIANG
;
Bin DU
Author Information
1. 南京中医药大学附属医院骨伤科,江苏南京 210029
- Keywords:
smart responsive materials;
femoral head osteonecrosis;
heterogeneity repair;
precise repair;
application prospects
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(7):841-847
- CountryChina
- Language:Chinese
-
Abstract:
Osteonecrosis of the femoral head(ONFH)is a common orthopedic disease,and hip preservation surgery has high clinical value in the early stages of ONFH,especially for young and middle-aged patients.However,the repair of ONFH is heterogeneous,leading to inter-individual variations in the efficacy of hip preservation.Currently,the existing tissue-engineered scaffolds in the field of hip preservation are uncontrollable after implantation,making it difficult to achieve precise repair.Smart responsive materials have good biocompatibility and self-feedback capability.By combining them with therapeutic drugs to construct stimulus-responsive drug delivery systems,new possibilities are provided for the precise repair of ONFH.This paper reviews the research progress of smart responsive materials at home and abroad.Based on the response principles of various materials and the repair characteristics of ONFH,the application prospects of various smart responsive materials such as reactive oxygen species-responsive,fluid shear stress-responsive,and light/magnetic-responsive materials are discussed and prospected in the field of precise repair for ONFH,providing new ideas for the precise treatment of ONFH.
