Research progress on the immune effects of photodynamic therapy
10.11855/j.issn.0577-7402.0454.2023.0921
- VernacularTitle:光动力疗法的抗肿瘤免疫效应研究进展
- Author:
Wen-Xin CHOU
1
;
Tian-Zhen SUN
;
Ying GU
;
Hong-You ZHAO
Author Information
1. 北京理工大学医学技术学院,北京 100081
- Keywords:
photodynamic therapy;
innate immunity;
specific immunity;
influence factors
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(6):718-725
- CountryChina
- Language:Chinese
-
Abstract:
As a novel tumor treatment,photodynamic therapy(PDT)has been widely used in clinical treatment of a variety of tumors due to its advantages,such as fewer adverse reactions,precise targeting and repeatability of treatment.Unlike conventional treatments,such as surgery,chemotherapy and radiotherapy,PDT not only eliminates the primary tumor but also effectively inhibits metastatic tumors by activating the body's immune response.However,the PDT-activated immune response is influenced by multiple factors,including the localization and dose of photosensitizer in the cells,light parameters,oxygen concentration in the tumor,and the integrity of immune function.This review summarizes the mechanisms behind the PDT-activated anti-tumor immune response,systematically examines the key influencing factors on the immune effect of PDT,and discusses the future development direction of PDT in cancer treatment.
