Progress in study of gut non-immune cells and their role in development of inflammatory bowel disease
10.11855/j.issn.0577-7402.1031.2024.0117
- VernacularTitle:肠道非免疫细胞及其在炎症性肠病中的作用研究进展
- Author:
Ze-Rui WANG
1
;
Yan-Mei JIAO
;
En-Qiang LINGHU
Author Information
1. 解放军总医院第一医学中心消化内科医学部,北京 100853
- Keywords:
inflammatory bowel disease;
ulcerative colitis;
Crohn's disease;
single-cell RNA sequencing;
epithelial cell;
mesenchymal cell
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(5):594-601
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is a kind of immune disease.Although immune cells and related immunological reactions play a crucial role in the pathogenesis,non-immune cells of IBD,including intestinal epithelial cells,stromal cells,and endothelial cells are also involved in this process.Recent studies have shown that gut non-immune cells play an important role in the maintenance of intestinal epithelial homeostasis,matrix remodeling,immune response and inflammation.The composition,gene expression characteristics and cell functions of gut non-immune cells,as well as their role in the occurrence and progression of IBD,have been paid much attention in the field of gut research.In particular,recently,single-cell RNA sequencing(scRNA-seq)technology has initially clarified the gene expression characteristics and cell functions of different subgroups of intestinal cells,and the correlation between these changes and the occurrence and progression of IBD.Therefore,this review summarizes the progress of intestinal non-immune cells in IBD.
