Research progress of the cancer-associated fibroblasts in breast cancer

VernacularTitle:肿瘤相关成纤维细胞在乳腺癌中的作用研究进展
Author: Yi-Zhu CHEN ¹ ; Li ZHU ; Yu-Fan WEI ; Xi-Ru LI
Author Information

1. 解放军医学院,北京 100853
Keywords: breast cancer; tumor microenvironment; cancer-associated fibroblasts
From: Medical Journal of Chinese People's Liberation Army 2024;49(4):482-488
CountryChina
Language:Chinese
Abstract: Breast cancer is one of the most prevalent malignancies in the world,and many advances have been made in various types of tumor research in recent years.With the deepening understanding of tumors,the microenvironment for tumor cell growth has attracted more and more attention for its impact on the development and progression of cancer.Cancer-associated fibroblasts(CAFs)as the most important components of the tumor microenvironment,can release cytokines,exosomes,and so forth in many ways to regulate immune microenvironment,remodel extracellular matrix and promote formation,migration,invasion,and resistance of tumors,while at the same time CAFs can be regulated by tumor cells.This paper attempts to explain the interaction mode between CAFs and tumors in the immune microenvironment and various ways in which CAFs can promote tumor proliferation,growth,invasion,metastasis,drug resistance and other malignant biological behaviors.Finally,the possibility of using CAFs as an early screening technique and new treatment method for breast tumors is discussed.