BUB1B and gynecological malignant tumors
10.16352/j.issn.1001-6325.2024.12.1717
- VernacularTitle:BUB1B与妇科恶性肿瘤
- Author:
Yiying HOU
1
;
Fang WEI
Author Information
1. 山西医科大学第二医院 妇产科,山西 太原 030000
- Keywords:
the BUB1 mitotic checkpoint serine/threonine kinase B(BUB1B);
gynecological malignant tumors;
mitosis
- From:
Basic & Clinical Medicine
2024;44(12):1717-1721
- CountryChina
- Language:Chinese
-
Abstract:
The BUB1 mitotic checkpoint serine/threonine kinase B(BUB1B)maintains a high fidelity of mitotic chromosome segregation by preventing the initiation of anaphase without the attachment of one or more kinetochore to the spindle,and plays a major role in both signal transduction and the stable attachment of kinetochore to micro-tubules.The dysregulated expression of BUB1B may affect the occurrence of mitosis-induced aneuploidy,chromo-some instability and abnormal cell biological function,leading to cell malignant transformation.This review summa-rizes the role of BUB1B in the occurrence and development of gynecological malignant tumors.
