Zinc transporter ZIP13 and diseases
10.16352/j.issn.1001-6325.2024.12.1712
- VernacularTitle:锌转运体ZIP13与疾病
- Author:
Huanhuan LI
1
;
Jing MA
;
Peipei DENG
;
Xuan LIU
;
Shusong WANG
Author Information
1. 河北省生殖健康医院 河北省生殖医学重点实验室,河北 石家庄 050071
- Keywords:
zinc transporter;
ZIP13;
Ehlers-Danlos syndrome;
ion transport
- From:
Basic & Clinical Medicine
2024;44(12):1712-1716
- CountryChina
- Language:Chinese
-
Abstract:
Zinc is an important regulator of various biological processes such as protein synthesis,cell proliferation,migration and autophagy.The zinc transporter ZIP13(SLC39A13)is a homodimeric metal transporter functioning in transport of zinc,iron,and calcium plasma in body.ZIP13 is involved in disease by regulating zinc homeostasis,such as the key role of ZIP13 in connective tissue development because it is involved in the BMP/TGF-β signaling pathway.ZIP13 promotes the metastasis of human ovarian cancer cells by activating the Src/FAK signaling pathway and ZIP13 inhibits the biogenesis and energy expenditure of beige adipocytes by regulating C/EBP-β expression.
