Progress of deacetylase SIRTs in pathogenesis of Parkinson's disease

VernacularTitle:去乙酰化酶SIRTs在帕金森病中的研究进展
Author: Xue FANG ¹ ; Jin SHI ; Haining LI ; Juan YANG
Author Information

1. 宁夏医科大学总医院神经内科,宁夏银川 750004
Keywords: Parkinson's disease; deacetylase Sirtuins; α-synuclein
From: Basic & Clinical Medicine 2024;44(11):1603-1607
CountryChina
Language:Chinese
Abstract: Sirtuins(SIRTs),a group of NAD+dependent deacetylases,have attracted considerable attention in the field of neuro-degenerative diseases,especially Parkinson's disease(PD).They have critical impacts on cell survival and death through modulation of various biological processes,such as intracellular metabolism,stress response and DNA repair.In the pathogenesis of PD,Sirtuins play a crucial role and associated with pathophysiological processes such as mitochondrial function,oxidative stress,and neuronal apoptosis.Activa-tion of Sirtuins alleviates dyskinesia and neuronal damage in animal models of PD and also regulates the aggre-gation and clearance of α-synuclein,a pathological feature of the disease.Therefore,the modulation of Sirtuins is a potential strategy for treating PD.