Mechanisms of arsenic induced gastric cancer
10.16352/j.issn.1001-6325.2024.11.1598
- VernacularTitle:砷致胃癌的作用机制
- Author:
Ling TONG
1
;
Jingwen ZHANG
;
Shuai LI
;
Kaipeng DUAN
Author Information
1. 苏州大学 苏州医学院 临床医学部,江苏 苏州 215006
- Keywords:
arsenic;
gastric cancer;
oxidative stress;
epigenetics;
immunoregulation
- From:
Basic & Clinical Medicine
2024;44(11):1598-1602
- CountryChina
- Language:Chinese
-
Abstract:
Arsenic is a heavy metal element and has been classified as group 1 carcinogens.Humans are mainly ex-posed to arsenic through drinking water.Long-term exposure to arsenic causes carcinomatous and non-carcinomatous lesions,including gastric carcinoma.At present,the known mechanisms of inorganic arsenic exposure leading to the occurrence and development of gastric cancer mainly include oxidative stress,epigenetic changes and immune regulation.Oxidative stress may change the structure and function of the intestinal epithelium,leading to damage to the intestinal mucosal barrier and then carcinoma.Epigenetic changes are mainly manifested in DNA methylation,histone post-translational modification and miRNA expression,which lead to the occurrence and development of gastric carcinoma.Impairment of the normal function of immune cells such as lymphocytes,dendritic cells,and macrophages may lead to dysbiosis of the gastrointestinal microbiota and development of gastric carcinoma.
